Drug interactions
Iloperidone + Repaglinide
Severity: Moderate
Iloperidone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone can inhibit CYP3A4 and may raise repaglinide exposure, increasing the risk of hypoglycemia. Atypical antipsychotics can also cause hyperglycemia, which may make glucose control unpredictable in either direction.
What this interaction means in plain words
Iloperidone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Time-dependent CYP3A inhibition by iloperidone may reduce repaglinide metabolism, combined with antipsychotic-related impairment of glucose regulation.
What to do
Monitor blood glucose closely when starting or stopping iloperidone and adjust the repaglinide dose as needed. Counsel the patient on recognizing hypoglycemia and hyperglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Repaglinide?
MediHelp rates the interaction as moderate. Iloperidone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone can inhibit CYP3A4 and may raise repaglinide exposure, increasing the risk of hypoglycemia. Atypical antipsychotics can also cause hyperglycemia, which may make glucose control unpredictable in either direction.
How serious is the interaction between Iloperidone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping iloperidone and adjust the repaglinide dose as needed. Counsel the patient on recognizing hypoglycemia and hyperglycemia.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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