Drug interactions
Iloperidone + Saxagliptin-metformin
Severity: Moderate
Iloperidone and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics including iloperidone can cause hyperglycemia and weight gain, which may offset antidiabetic therapy. Iloperidone also weakly inhibits CYP3A4, which may modestly raise saxagliptin exposure.
What this interaction means in plain words
Iloperidone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance, plus weak CYP3A4 inhibition reducing saxagliptin metabolism.
What to do
Monitor fasting glucose and HbA1c regularly and adjust antidiabetic therapy as needed. No empirical saxagliptin dose change is required, but watch for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Iloperidone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics including iloperidone can cause hyperglycemia and weight gain, which may offset antidiabetic therapy. Iloperidone also weakly inhibits CYP3A4, which may modestly raise saxagliptin exposure.
How serious is the interaction between Iloperidone and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly and adjust antidiabetic therapy as needed. No empirical saxagliptin dose change is required, but watch for adverse effects.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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