Drug interactions
Iloperidone + Sertraline
Severity: Major
Iloperidone and Sertraline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval, and sertraline adds a smaller effect. Sertraline may also modestly inhibit CYP2D6, raising iloperidone exposure, so both pharmacodynamic and kinetic effects can increase arrhythmic risk.
What this interaction means in plain words
Iloperidone and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus CYP2D6 inhibition by sertraline that can raise iloperidone levels.
What to do
Obtain a baseline ECG and electrolytes, and monitor the ECG when starting or increasing sertraline. Consider a lower iloperidone dose or an alternative antipsychotic in patients at cardiac risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Sertraline?
MediHelp rates the interaction as major. Iloperidone and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone prolongs the QT interval, and sertraline adds a smaller effect. Sertraline may also modestly inhibit CYP2D6, raising iloperidone exposure, so both pharmacodynamic and kinetic effects can increase arrhythmic risk.
How serious is the interaction between Iloperidone and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes, and monitor the ECG when starting or increasing sertraline. Consider a lower iloperidone dose or an alternative antipsychotic in patients at cardiac risk.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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