Drug interactions
Iloperidone + Simvastatin
Severity: Moderate
Iloperidone and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone may inhibit CYP3A4 and could increase simvastatin exposure. Elevated simvastatin levels raise the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Iloperidone and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Simvastatin belongs to Cardiovascular.
Why it happens
Iloperidone inhibits CYP3A4, reducing simvastatin clearance.
What to do
Monitor for muscle symptoms and consider limiting the simvastatin dose or choosing a non-CYP3A4 statin. Measure CK if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Simvastatin?
MediHelp rates the interaction as moderate. Iloperidone and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone may inhibit CYP3A4 and could increase simvastatin exposure. Elevated simvastatin levels raise the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Iloperidone and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider limiting the simvastatin dose or choosing a non-CYP3A4 statin. Measure CK if symptoms arise.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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