Drug interactions
Iloperidone + Sumatriptan
Severity: Minor
Iloperidone and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an atypical antipsychotic with 5-HT2A antagonism and dopamine blockade. Combined with a triptan, there are theoretical risks of serotonin syndrome or neuroleptic malignant syndrome, though clinical reports are scarce.
What this interaction means in plain words
Iloperidone and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Theoretical overlapping serotonergic and dopaminergic effects; the mechanism is not firmly established.
What to do
Be aware of the theoretical risk. Counsel patients to report fever, rigidity, confusion or autonomic instability, and evaluate promptly for serotonin syndrome or NMS if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Sumatriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Sumatriptan?
MediHelp rates the interaction as minor. Iloperidone and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is an atypical antipsychotic with 5-HT2A antagonism and dopamine blockade. Combined with a triptan, there are theoretical risks of serotonin syndrome or neuroleptic malignant syndrome, though clinical reports are scarce.
How serious is the interaction between Iloperidone and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of the theoretical risk. Counsel patients to report fever, rigidity, confusion or autonomic instability, and evaluate promptly for serotonin syndrome or NMS if they occur.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
