Drug interactions
Iloperidone + Tamsulosin
Severity: Moderate
Iloperidone and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is itself an alpha-blocking antipsychotic and a weak CYP3A4 and CYP2D6 inhibitor. Combining it with tamsulosin may add to orthostatic hypotension and raise tamsulosin levels.
What this interaction means in plain words
Iloperidone and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade plus inhibition of CYP3A4 and CYP2D6 metabolism of tamsulosin.
What to do
Monitor orthostatic blood pressure, especially during iloperidone titration. Reduce the dose of either drug if dizziness or syncope occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Tamsulosin?
MediHelp rates the interaction as moderate. Iloperidone and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is itself an alpha-blocking antipsychotic and a weak CYP3A4 and CYP2D6 inhibitor. Combining it with tamsulosin may add to orthostatic hypotension and raise tamsulosin levels.
How serious is the interaction between Iloperidone and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure, especially during iloperidone titration. Reduce the dose of either drug if dizziness or syncope occurs.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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