Drug interactions
Iloperidone + Tiotropium
Severity: Minor
Iloperidone and Tiotropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has some anticholinergic activity and may add to the antimuscarinic effects of tiotropium, such as dry mouth, constipation and urinary retention. The legacy claims of reduced absorption and hypoglycemia are not well founded. The clinical significance is generally modest.
What this interaction means in plain words
Iloperidone and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Tiotropium belongs to Respiratory.
Why it happens
Weak additive antimuscarinic effects at muscarinic receptors.
What to do
Monitor for anticholinergic symptoms, particularly in older patients or those with urinary retention or glaucoma. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Tiotropium?
MediHelp rates the interaction as minor. Iloperidone and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone has some anticholinergic activity and may add to the antimuscarinic effects of tiotropium, such as dry mouth, constipation and urinary retention. The legacy claims of reduced absorption and hypoglycemia are not well founded. The clinical significance is generally modest.
How serious is the interaction between Iloperidone and Tiotropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, particularly in older patients or those with urinary retention or glaucoma. No dose change is usually required.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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