Drug interactions
Iloperidone + Tolazamide
Severity: Moderate
Iloperidone and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can worsen glycemic control and may cause hyperglycemia or new-onset diabetes. This can counteract tolazamide and lead to loss of glucose control.
What this interaction means in plain words
Iloperidone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Tolazamide belongs to Endocrine.
Why it happens
Antipsychotic-related insulin resistance and metabolic effects oppose the hypoglycemic action of the sulfonylurea.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone. Titrate tolazamide or add other therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Tolazamide?
MediHelp rates the interaction as moderate. Iloperidone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can worsen glycemic control and may cause hyperglycemia or new-onset diabetes. This can counteract tolazamide and lead to loss of glucose control.
How serious is the interaction between Iloperidone and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone. Titrate tolazamide or add other therapy if control worsens.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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