Drug interactions
Iloperidone + Tranylcypromine
Severity: Moderate
Iloperidone and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an MAO inhibitor with an antipsychotic may increase the risk of serotonin toxicity or neuroleptic malignant syndrome, although such events are uncommon. Iloperidone also causes orthostatic hypotension, which may be additive with MAO inhibitor effects.
What this interaction means in plain words
Iloperidone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Combined serotonergic and dopaminergic modulation plus additive hypotensive effects; precise mechanism is not firmly established.
What to do
Monitor for hyperthermia, rigidity, mental status change and autonomic instability, as well as orthostatic blood pressure. Titrate iloperidone slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Tranylcypromine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Tranylcypromine?
MediHelp rates the interaction as moderate. Iloperidone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an MAO inhibitor with an antipsychotic may increase the risk of serotonin toxicity or neuroleptic malignant syndrome, although such events are uncommon. Iloperidone also causes orthostatic hypotension, which may be additive with MAO inhibitor effects.
How serious is the interaction between Iloperidone and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, mental status change and autonomic instability, as well as orthostatic blood pressure. Titrate iloperidone slowly.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
