Drug interactions
Iloperidone + Vardenafil
Severity: Moderate
Iloperidone and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and iloperidone may also modestly raise vardenafil levels through CYP3A inhibition. Together this may increase the risk of QT-related ventricular arrhythmia and hypotension.
What this interaction means in plain words
Iloperidone and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Additive QT prolongation plus possible weak CYP3A4 inhibition by iloperidone raising vardenafil exposure.
What to do
Use the lowest effective vardenafil dose and monitor ECG in patients with cardiac risk factors or electrolyte disturbances. Correct potassium and magnesium abnormalities beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Vardenafil?
MediHelp rates the interaction as moderate. Iloperidone and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and iloperidone may also modestly raise vardenafil levels through CYP3A inhibition. Together this may increase the risk of QT-related ventricular arrhythmia and hypotension.
How serious is the interaction between Iloperidone and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective vardenafil dose and monitor ECG in patients with cardiac risk factors or electrolyte disturbances. Correct potassium and magnesium abnormalities beforehand.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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