Drug interactions
Iloperidone + Ziprasidone
Severity: Major
Iloperidone and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antipsychotics prolong the QT interval, so combining them increases the risk of torsades de pointes and sudden cardiac death. Additive sedation, orthostatic hypotension and extrapyramidal effects can also occur.
What this interaction means in plain words
Iloperidone and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade, plus additive dopamine antagonism and sedation.
What to do
Avoid concurrent use; ziprasidone labeling advises against combination with other QT-prolonging drugs. If a switch is underway, cross-taper and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Ziprasidone?
MediHelp rates the interaction as major. Iloperidone and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both antipsychotics prolong the QT interval, so combining them increases the risk of torsades de pointes and sudden cardiac death. Additive sedation, orthostatic hypotension and extrapyramidal effects can also occur.
How serious is the interaction between Iloperidone and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; ziprasidone labeling advises against combination with other QT-prolonging drugs. If a switch is underway, cross-taper and monitor ECG and electrolytes.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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