Drug interactions
Iloprost + Pramipexole
Severity: Moderate
Iloprost and Pramipexole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator and pramipexole can cause orthostatic hypotension, so the combination may produce additive blood pressure lowering. This is most relevant during intravenous iloprost infusion.
What this interaction means in plain words
Iloprost and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Pramipexole belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from prostacyclin-mediated vasodilation and dopamine agonist-related orthostatic hypotension.
What to do
Monitor blood pressure during iloprost initiation and titration, and reduce the iloprost dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Pramipexole?
MediHelp rates the interaction as moderate. Iloprost and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator and pramipexole can cause orthostatic hypotension, so the combination may produce additive blood pressure lowering. This is most relevant during intravenous iloprost infusion.
How serious is the interaction between Iloprost and Pramipexole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during iloprost initiation and titration, and reduce the iloprost dose if symptomatic hypotension occurs.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
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