Drug interactions
Imatinib + Lasmiditan
Severity: Minor
Imatinib and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-gp and BCRP in vitro and could increase imatinib exposure. The clinical relevance is uncertain, since lasmiditan is typically used intermittently.
What this interaction means in plain words
Imatinib and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits P-gp and BCRP efflux transporters, possibly increasing imatinib absorption.
What to do
Monitor for imatinib adverse effects after lasmiditan doses; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Imatinib with Lasmiditan?
MediHelp rates the interaction as minor. Imatinib and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-gp and BCRP in vitro and could increase imatinib exposure. The clinical relevance is uncertain, since lasmiditan is typically used intermittently.
How serious is the interaction between Imatinib and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib adverse effects after lasmiditan doses; no routine dose change is needed.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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