Drug interactions
Imatinib + Letermovir
Severity: Moderate
Imatinib and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 and OATP1B1/3 and may increase imatinib exposure. Higher imatinib levels could worsen fluid retention, cytopenias and liver toxicity.
What this interaction means in plain words
Imatinib and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Letermovir belongs to Anti Virals.
Why it happens
Letermovir is a moderate CYP3A4 inhibitor and OATP1B1/3 inhibitor, reducing imatinib clearance.
What to do
Monitor blood counts, liver function and fluid status, and reduce the imatinib dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Imatinib with Letermovir?
MediHelp rates the interaction as moderate. Imatinib and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 and OATP1B1/3 and may increase imatinib exposure. Higher imatinib levels could worsen fluid retention, cytopenias and liver toxicity.
How serious is the interaction between Imatinib and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver function and fluid status, and reduce the imatinib dose if toxicity appears.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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