Drug interactions
Imatinib + Levomilnacipran
Severity: Moderate
Imatinib and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is cleared in part by CYP3A4, and imatinib may increase its exposure. This may increase nausea, blood pressure and heart rate, and serotonergic effects.
What this interaction means in plain words
Imatinib and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Levomilnacipran belongs to Central Nervous System.
Why it happens
Imatinib inhibits CYP3A4 metabolism of levomilnacipran.
What to do
Monitor blood pressure, heart rate and serotonergic symptoms, and keep the levomilnacipran dose at or below 80 mg/day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Imatinib with Levomilnacipran?
MediHelp rates the interaction as moderate. Imatinib and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran is cleared in part by CYP3A4, and imatinib may increase its exposure. This may increase nausea, blood pressure and heart rate, and serotonergic effects.
How serious is the interaction between Imatinib and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serotonergic symptoms, and keep the levomilnacipran dose at or below 80 mg/day.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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