Drug interactions
Imatinib + Ospemifene
Severity: Moderate
Imatinib and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ospemifene is metabolized by CYP3A4 and CYP2C9, and imatinib is a moderate CYP3A4 inhibitor. Exposure to ospemifene may increase, raising the risk of adverse effects such as hot flushes, thromboembolic events and endometrial effects.
What this interaction means in plain words
Imatinib and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Ospemifene belongs to Endocrine.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of ospemifene.
What to do
Monitor for ospemifene adverse effects, particularly thromboembolic symptoms and unexpected vaginal bleeding. Consider an alternative if the adverse effects become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Imatinib with Ospemifene?
MediHelp rates the interaction as moderate. Imatinib and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ospemifene is metabolized by CYP3A4 and CYP2C9, and imatinib is a moderate CYP3A4 inhibitor. Exposure to ospemifene may increase, raising the risk of adverse effects such as hot flushes, thromboembolic events and endometrial effects.
How serious is the interaction between Imatinib and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ospemifene adverse effects, particularly thromboembolic symptoms and unexpected vaginal bleeding. Consider an alternative if the adverse effects become troublesome.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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