Drug interactions
Imatinib + Oteseconazole
Severity: Minor
Imatinib and Oteseconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP, so imatinib exposure may increase. The clinical significance is likely small with short courses, but cytopenias and fluid retention could be more likely.
What this interaction means in plain words
Imatinib and Oteseconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Oteseconazole belongs to Anti Fungals.
Why it happens
Oteseconazole inhibits BCRP, reducing efflux of imatinib.
What to do
Monitor blood counts and signs of imatinib toxicity during and after oteseconazole therapy, and reduce the imatinib dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Imatinib with Oteseconazole?
MediHelp rates the interaction as minor. Imatinib and Oteseconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oteseconazole inhibits BCRP, so imatinib exposure may increase. The clinical significance is likely small with short courses, but cytopenias and fluid retention could be more likely.
How serious is the interaction between Imatinib and Oteseconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of imatinib toxicity during and after oteseconazole therapy, and reduce the imatinib dose if toxicity develops.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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