Drug interactions
Imatinib + Piroxicam
Severity: Moderate
Imatinib and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and GI bleeding, and piroxicam adds platelet inhibition and gastric mucosal injury. Bleeding risk is therefore increased.
What this interaction means in plain words
Imatinib and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Piroxicam belongs to Musculoskeletal.
Why it happens
Additive hemorrhagic risk from imatinib-related thrombocytopenia and NSAID platelet inhibition; imatinib may weakly inhibit CYP2C9, raising piroxicam exposure.
What to do
Monitor blood counts and watch for bleeding or GI symptoms. Prefer paracetamol for analgesia and consider gastroprotection if an NSAID is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Piroxicam?
MediHelp rates the interaction as moderate. Imatinib and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and GI bleeding, and piroxicam adds platelet inhibition and gastric mucosal injury. Bleeding risk is therefore increased.
How serious is the interaction between Imatinib and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for bleeding or GI symptoms. Prefer paracetamol for analgesia and consider gastroprotection if an NSAID is needed.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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