Drug interactions
Imatinib + Rimegepant
Severity: Moderate
Imatinib and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4, which is a main route of rimegepant elimination, so rimegepant exposure increases. This may raise the chance of adverse effects such as nausea and hypersensitivity reactions.
What this interaction means in plain words
Imatinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Rimegepant belongs to Central Nervous System.
Why it happens
Imatinib inhibition of CYP3A4 reduces rimegepant metabolism.
What to do
Avoid a second rimegepant dose within 48 hours when taken with imatinib. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Rimegepant
Frequently asked questions
Can I take Imatinib with Rimegepant?
MediHelp rates the interaction as moderate. Imatinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4, which is a main route of rimegepant elimination, so rimegepant exposure increases. This may raise the chance of adverse effects such as nausea and hypersensitivity reactions.
How serious is the interaction between Imatinib and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when taken with imatinib. Monitor for adverse effects.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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