Drug interactions
Imatinib + Rivaroxaban
Severity: Moderate
Imatinib and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and bleeding, which adds to the hemorrhagic risk of rivaroxaban. Imatinib is also a CYP3A4 inhibitor and may modestly raise rivaroxaban exposure.
What this interaction means in plain words
Imatinib and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Rivaroxaban belongs to Cardiovascular.
Why it happens
Additive bleeding risk from imatinib thrombocytopenia plus anticoagulation, with possible weak CYP3A4 and P-gp inhibition increasing rivaroxaban levels.
What to do
Monitor platelet counts and signs of bleeding during combined use. Hold or reduce anticoagulation if marked thrombocytopenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Rivaroxaban?
MediHelp rates the interaction as moderate. Imatinib and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and bleeding, which adds to the hemorrhagic risk of rivaroxaban. Imatinib is also a CYP3A4 inhibitor and may modestly raise rivaroxaban exposure.
How serious is the interaction between Imatinib and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and signs of bleeding during combined use. Hold or reduce anticoagulation if marked thrombocytopenia develops.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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