Drug interactions
Imatinib + Saxagliptin
Severity: Moderate
Imatinib and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may raise saxagliptin and its active metabolite levels. Imatinib is a moderate rather than strong inhibitor, so the effect is usually smaller than with ketoconazole-type inhibitors.
What this interaction means in plain words
Imatinib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Saxagliptin belongs to Endocrine.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of saxagliptin.
What to do
Monitor glucose and for saxagliptin adverse effects such as hypoglycemia with other agents. Limiting saxagliptin to 2.5 mg daily is advised only with strong CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Saxagliptin?
MediHelp rates the interaction as moderate. Imatinib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and may raise saxagliptin and its active metabolite levels. Imatinib is a moderate rather than strong inhibitor, so the effect is usually smaller than with ketoconazole-type inhibitors.
How serious is the interaction between Imatinib and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and for saxagliptin adverse effects such as hypoglycemia with other agents. Limiting saxagliptin to 2.5 mg daily is advised only with strong CYP3A4 inhibitors.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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