Drug interactions
Imatinib + Sonidegib
Severity: Moderate
Imatinib and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase sonidegib exposure, raising the risk of musculoskeletal toxicity such as myopathy and rhabdomyolysis.
What this interaction means in plain words
Imatinib and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Sonidegib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, which metabolizes sonidegib.
What to do
Monitor creatine kinase and muscle symptoms. If moderate inhibitor use exceeds 14 days, consider alternatives or dose limitation per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Imatinib with Sonidegib?
MediHelp rates the interaction as moderate. Imatinib and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase sonidegib exposure, raising the risk of musculoskeletal toxicity such as myopathy and rhabdomyolysis.
How serious is the interaction between Imatinib and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatine kinase and muscle symptoms. If moderate inhibitor use exceeds 14 days, consider alternatives or dose limitation per labeling.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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