Drug interactions
Imatinib + Tafamidis
Severity: Minor
Imatinib and Tafamidis: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro and may modestly increase exposure to BCRP substrates such as imatinib. Clinical significance is uncertain.
What this interaction means in plain words
Imatinib and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Tafamidis belongs to Cardiovascular.
Why it happens
Tafamidis inhibits BCRP-mediated efflux of imatinib.
What to do
Monitor for imatinib adverse effects such as edema and cytopenias, and adjust the dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Imatinib with Tafamidis?
MediHelp rates the interaction as minor. Imatinib and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis inhibits BCRP in vitro and may modestly increase exposure to BCRP substrates such as imatinib. Clinical significance is uncertain.
How serious is the interaction between Imatinib and Tafamidis?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib adverse effects such as edema and cytopenias, and adjust the dose if toxicity develops.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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