Drug interactions
Imatinib + Tazemetostat
Severity: Major
Imatinib and Tazemetostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and can increase tazemetostat concentrations. This raises the risk of tazemetostat adverse effects.
What this interaction means in plain words
Imatinib and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imatinib belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of tazemetostat.
What to do
Avoid the combination if possible. If unavoidable, reduce the tazemetostat dose as in its labeling for moderate CYP3A inhibitors and monitor for adverse reactions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Imatinib with Tazemetostat?
MediHelp rates the interaction as major. Imatinib and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib is a moderate CYP3A4 inhibitor and can increase tazemetostat concentrations. This raises the risk of tazemetostat adverse effects.
How serious is the interaction between Imatinib and Tazemetostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If unavoidable, reduce the tazemetostat dose as in its labeling for moderate CYP3A inhibitors and monitor for adverse reactions.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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