Drug interactions
Imatinib + Tipranavir
Severity: Major
Imatinib and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir given with ritonavir strongly inhibits CYP3A4 and may substantially increase imatinib levels. This increases the risk of imatinib toxicity such as edema, myelosuppression and hepatotoxicity. Tipranavir also has a mixed inducing effect, making the net result less predictable.
What this interaction means in plain words
Imatinib and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imatinib belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 metabolism of imatinib by ritonavir-boosted tipranavir.
What to do
Prefer an alternative antiretroviral. If coadministered, monitor blood counts, liver function and fluid status and consider reducing the imatinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Imatinib with Tipranavir?
MediHelp rates the interaction as major. Imatinib and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir given with ritonavir strongly inhibits CYP3A4 and may substantially increase imatinib levels. This increases the risk of imatinib toxicity such as edema, myelosuppression and hepatotoxicity. Tipranavir also has a mixed inducing effect, making the net result less predictable.
How serious is the interaction between Imatinib and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antiretroviral. If coadministered, monitor blood counts, liver function and fluid status and consider reducing the imatinib dose.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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