Drug interactions
Imatinib + Trastuzumab deruxtecan
Severity: Moderate
Imatinib and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neutropenia and other myelosuppression, so combined use may increase infection risk. Trastuzumab deruxtecan additionally causes interstitial lung disease and cardiac toxicity.
What this interaction means in plain words
Imatinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression through different pharmacodynamic mechanisms.
What to do
Monitor complete blood counts regularly and manage neutropenia with dose interruption or reduction per labeling. Counsel patients to report fever or respiratory symptoms promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Imatinib with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Imatinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neutropenia and other myelosuppression, so combined use may increase infection risk. Trastuzumab deruxtecan additionally causes interstitial lung disease and cardiac toxicity.
How serious is the interaction between Imatinib and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and manage neutropenia with dose interruption or reduction per labeling. Counsel patients to report fever or respiratory symptoms promptly.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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