Drug interactions
Imatinib + Voriconazole
Severity: Moderate
Imatinib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises imatinib levels via CYP3A4 inhibition, and imatinib may in turn raise voriconazole levels by inhibiting CYP2C9, CYP2C19, and CYP3A4. This may increase adverse effects of both, including edema, myelosuppression, and QT effects.
What this interaction means in plain words
Imatinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Mutual inhibition of CYP enzymes, mainly CYP3A4 for imatinib and CYP2C9/2C19 for voriconazole.
What to do
Monitor blood counts, liver tests, and the ECG, and watch for signs of toxicity from either drug. Reduce the imatinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Voriconazole?
MediHelp rates the interaction as moderate. Imatinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole raises imatinib levels via CYP3A4 inhibition, and imatinib may in turn raise voriconazole levels by inhibiting CYP2C9, CYP2C19, and CYP3A4. This may increase adverse effects of both, including edema, myelosuppression, and QT effects.
How serious is the interaction between Imatinib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver tests, and the ECG, and watch for signs of toxicity from either drug. Reduce the imatinib dose if toxicity develops.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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