Drug interactions
Imidapril + Ketoprofen
Severity: Moderate
Imidapril and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of ACE inhibitors such as imidapril. The combination also increases the risk of acute kidney injury and hyperkalemia, particularly in older, volume-depleted or renally impaired patients.
What this interaction means in plain words
Imidapril and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and renal afferent arteriolar dilation opposes ACE inhibitor effect and, with reduced angiotensin II, impairs glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest NSAID dose for the shortest duration or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Ketoprofen?
MediHelp rates the interaction as moderate. Imidapril and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of ACE inhibitors such as imidapril. The combination also increases the risk of acute kidney injury and hyperkalemia, particularly in older, volume-depleted or renally impaired patients.
How serious is the interaction between Imidapril and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest NSAID dose for the shortest duration or choose an alternative analgesic.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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