Drug interactions
Imidapril + Linagliptin-metformin
Severity: Moderate
Imidapril and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in at-risk patients, which raises metformin accumulation and lactic acidosis risk.
What this interaction means in plain words
Imidapril and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
ACE inhibition may improve insulin sensitivity, and renal function decline can reduce metformin elimination.
What to do
Monitor blood glucose and renal function (eGFR) at initiation and periodically. Reduce or stop metformin if renal function deteriorates significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Imidapril and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in at-risk patients, which raises metformin accumulation and lactic acidosis risk.
How serious is the interaction between Imidapril and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function (eGFR) at initiation and periodically. Reduce or stop metformin if renal function deteriorates significantly.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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