Drug interactions
Imidapril + Phentolamine
Severity: Moderate
Imidapril and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, and together they may cause excessive hypotension, particularly after the first dose of the ACE inhibitor. Dizziness and syncope are possible.
What this interaction means in plain words
Imidapril and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive vasodilatory and antihypertensive effects via alpha-blockade and ACE inhibition.
What to do
Start imidapril at a low dose and monitor blood pressure, especially after the first dose. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imidapril and Phentolamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Phentolamine
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Phentolamine?
MediHelp rates the interaction as moderate. Imidapril and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, and together they may cause excessive hypotension, particularly after the first dose of the ACE inhibitor. Dizziness and syncope are possible.
How serious is the interaction between Imidapril and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start imidapril at a low dose and monitor blood pressure, especially after the first dose. Advise patients to rise slowly.
What other medicines interact with Phentolamine?
MediHelp also lists interactions of Phentolamine with, for example, Alfuzosin, Avanafil, Doxazosin. The full list is on the Phentolamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
