Drug interactions
Imidapril + Saxagliptin-metformin
Severity: Moderate
Imidapril and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Acute kidney injury from ACE inhibitors may also reduce metformin clearance and raise the risk of lactic acidosis.
What this interaction means in plain words
Imidapril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
ACE inhibition may enhance insulin sensitivity, and renal function decline may reduce metformin elimination.
What to do
Monitor blood glucose and renal function, especially at initiation or with dehydration, and adjust or stop metformin if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Imidapril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Acute kidney injury from ACE inhibitors may also reduce metformin clearance and raise the risk of lactic acidosis.
How serious is the interaction between Imidapril and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, especially at initiation or with dehydration, and adjust or stop metformin if renal function deteriorates.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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