Drug interactions
Imidapril + Tolbutamide
Severity: Minor
Imidapril and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and have been associated with enhanced glucose lowering and hypoglycemia in patients using sulfonylureas. The effect is generally modest.
What this interaction means in plain words
Imidapril and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imidapril belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Improved insulin sensitivity with ACE inhibition produces additive glucose lowering; mechanism not fully established.
What to do
Be aware of the potential for hypoglycemia and check blood glucose when starting imidapril, adjusting the tolbutamide dose only if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Tolbutamide?
MediHelp rates the interaction as minor. Imidapril and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may increase insulin sensitivity and have been associated with enhanced glucose lowering and hypoglycemia in patients using sulfonylureas. The effect is generally modest.
How serious is the interaction between Imidapril and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of the potential for hypoglycemia and check blood glucose when starting imidapril, adjusting the tolbutamide dose only if needed.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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