Drug interactions
Imipramine + Indacaterol
Severity: Major
Imipramine and Indacaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can prolong the QT interval and have cardiovascular effects that may be potentiated by beta-2 agonists. Combined use raises the risk of ventricular arrhythmias and tachycardia.
What this interaction means in plain words
Imipramine and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imipramine belongs to Central Nervous System; Indacaterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization and sympathomimetic cardiovascular stimulation; beta-2 agonist also causes hypokalemia.
What to do
Obtain a baseline ECG and monitor QTc and heart rate during co-therapy, and correct potassium and magnesium. Consider an alternative to the tricyclic if QTc lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Indacaterol?
MediHelp rates the interaction as major. Imipramine and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can prolong the QT interval and have cardiovascular effects that may be potentiated by beta-2 agonists. Combined use raises the risk of ventricular arrhythmias and tachycardia.
How serious is the interaction between Imipramine and Indacaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and heart rate during co-therapy, and correct potassium and magnesium. Consider an alternative to the tricyclic if QTc lengthens.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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