Drug interactions
Imipramine + Melatonin
Severity: Minor
Imipramine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin may add to the drowsiness caused by imipramine. The effect is generally mild and may even be useful for insomnia, though daytime impairment can occur.
What this interaction means in plain words
Imipramine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive sedative effects; melatonin is also partly metabolized by CYP1A2 but no significant imipramine kinetic change is established.
What to do
Take melatonin at bedtime and counsel about daytime drowsiness and driving. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Imipramine with Melatonin?
MediHelp rates the interaction as minor. Imipramine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin may add to the drowsiness caused by imipramine. The effect is generally mild and may even be useful for insomnia, though daytime impairment can occur.
How serious is the interaction between Imipramine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take melatonin at bedtime and counsel about daytime drowsiness and driving. No dose change is usually needed.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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