Drug interactions
Imipramine + Nefopam
Severity: Moderate
Imipramine and Nefopam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefopam has sympathomimetic and anticholinergic properties and inhibits monoamine reuptake. With imipramine it may increase tachycardia, anticholinergic effects, seizure risk and possibly serotonergic effects.
What this interaction means in plain words
Imipramine and Nefopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Nefopam belongs to Central Nervous System.
Why it happens
Additive anticholinergic, sympathomimetic and monoamine reuptake inhibition effects.
What to do
Monitor heart rate, anticholinergic effects and CNS symptoms such as agitation, tremor or seizures. Avoid in patients with epilepsy or significant cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Nefopam
- Amitriptyline + Nefopam Moderate
- Clomipramine + Nefopam Moderate
- Desipramine + Nefopam Moderate
- Maprotiline + Nefopam Moderate
- Nefopam + Nortriptyline Moderate
- Nefopam + Trazodone Moderate
Frequently asked questions
Can I take Imipramine with Nefopam?
MediHelp rates the interaction as moderate. Imipramine and Nefopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefopam has sympathomimetic and anticholinergic properties and inhibits monoamine reuptake. With imipramine it may increase tachycardia, anticholinergic effects, seizure risk and possibly serotonergic effects.
How serious is the interaction between Imipramine and Nefopam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, anticholinergic effects and CNS symptoms such as agitation, tremor or seizures. Avoid in patients with epilepsy or significant cardiac disease.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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