Drug interactions
Desipramine + Nefopam
Severity: Moderate
Desipramine and Nefopam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefopam has sympathomimetic and anticholinergic properties and inhibits monoamine reuptake. Combined with a tricyclic antidepressant it may cause tachycardia, anticholinergic effects, and rarely seizures or serotonergic effects.
What this interaction means in plain words
Desipramine and Nefopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Nefopam belongs to Central Nervous System.
Why it happens
Additive monoamine reuptake inhibition and anticholinergic effects.
What to do
Monitor heart rate, anticholinergic effects and for signs of serotonin toxicity or seizures. Avoid the combination in patients with seizure history or heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Nefopam
- Amitriptyline + Nefopam Moderate
- Clomipramine + Nefopam Moderate
- Imipramine + Nefopam Moderate
- Maprotiline + Nefopam Moderate
- Nefopam + Nortriptyline Moderate
- Nefopam + Trazodone Moderate
Frequently asked questions
Can I take Desipramine with Nefopam?
MediHelp rates the interaction as moderate. Desipramine and Nefopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefopam has sympathomimetic and anticholinergic properties and inhibits monoamine reuptake. Combined with a tricyclic antidepressant it may cause tachycardia, anticholinergic effects, and rarely seizures or serotonergic effects.
How serious is the interaction between Desipramine and Nefopam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, anticholinergic effects and for signs of serotonin toxicity or seizures. Avoid the combination in patients with seizure history or heart disease.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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