Drug interactions
Nefopam + Trazodone
Severity: Moderate
Nefopam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefopam has sympathomimetic and anticholinergic properties and may cause sedation, sweating and tachycardia. Combined with trazodone this might add to anticholinergic and serotonergic effects, but the interaction is poorly documented.
What this interaction means in plain words
Nefopam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nefopam belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Possible additive anticholinergic, sympathomimetic and monoamine reuptake effects; not well established.
What to do
Use the lowest effective doses and monitor heart rate, blood pressure and agitation. Stop nefopam if serotonin toxicity or marked tachycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Nefopam
- Amitriptyline + Nefopam Moderate
- Clomipramine + Nefopam Moderate
- Desipramine + Nefopam Moderate
- Imipramine + Nefopam Moderate
- Maprotiline + Nefopam Moderate
- Nefopam + Nortriptyline Moderate
Frequently asked questions
Can I take Nefopam with Trazodone?
MediHelp rates the interaction as moderate. Nefopam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefopam has sympathomimetic and anticholinergic properties and may cause sedation, sweating and tachycardia. Combined with trazodone this might add to anticholinergic and serotonergic effects, but the interaction is poorly documented.
How serious is the interaction between Nefopam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor heart rate, blood pressure and agitation. Stop nefopam if serotonin toxicity or marked tachycardia develops.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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