Drug interactions
Clomipramine + Nefopam
Severity: Moderate
Clomipramine and Nefopam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefopam has anticholinergic and sympathomimetic effects and inhibits monoamine reuptake. Combined with a tricyclic it may increase tachycardia, anticholinergic effects, seizure risk and possibly serotonergic effects.
What this interaction means in plain words
Clomipramine and Nefopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Nefopam belongs to Central Nervous System.
Why it happens
Additive anticholinergic, sympathomimetic and monoamine reuptake inhibition effects.
What to do
Monitor heart rate, anticholinergic effects and mental status. Avoid the combination in patients with seizure disorders or cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Nefopam
- Amitriptyline + Nefopam Moderate
- Desipramine + Nefopam Moderate
- Imipramine + Nefopam Moderate
- Maprotiline + Nefopam Moderate
- Nefopam + Nortriptyline Moderate
- Nefopam + Trazodone Moderate
Frequently asked questions
Can I take Clomipramine with Nefopam?
MediHelp rates the interaction as moderate. Clomipramine and Nefopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefopam has anticholinergic and sympathomimetic effects and inhibits monoamine reuptake. Combined with a tricyclic it may increase tachycardia, anticholinergic effects, seizure risk and possibly serotonergic effects.
How serious is the interaction between Clomipramine and Nefopam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, anticholinergic effects and mental status. Avoid the combination in patients with seizure disorders or cardiac disease.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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