Drug interactions
Maprotiline + Nefopam
Severity: Moderate
Maprotiline and Nefopam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefopam has anticholinergic and sympathomimetic properties and can cause tachycardia, sedation and, rarely, seizures. With maprotiline, additive anticholinergic effects, tachycardia and a lower seizure threshold are plausible.
What this interaction means in plain words
Maprotiline and Nefopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Nefopam belongs to Central Nervous System.
Why it happens
Additive anticholinergic and monoamine reuptake effects; no formal mechanism has been established for the combination.
What to do
Monitor heart rate, anticholinergic effects and seizure risk, and avoid the combination in patients with epilepsy or cardiac disease. Choose a different analgesic if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Nefopam
- Amitriptyline + Nefopam Moderate
- Clomipramine + Nefopam Moderate
- Desipramine + Nefopam Moderate
- Imipramine + Nefopam Moderate
- Nefopam + Nortriptyline Moderate
- Nefopam + Trazodone Moderate
Frequently asked questions
Can I take Maprotiline with Nefopam?
MediHelp rates the interaction as moderate. Maprotiline and Nefopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefopam has anticholinergic and sympathomimetic properties and can cause tachycardia, sedation and, rarely, seizures. With maprotiline, additive anticholinergic effects, tachycardia and a lower seizure threshold are plausible.
How serious is the interaction between Maprotiline and Nefopam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, anticholinergic effects and seizure risk, and avoid the combination in patients with epilepsy or cardiac disease. Choose a different analgesic if adverse effects occur.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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