Drug interactions
Imipramine + Pregabalin
Severity: Moderate
Imipramine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, dizziness and impaired psychomotor performance, which can be additive. Respiratory depression is a concern in vulnerable patients or with other CNS depressants.
What this interaction means in plain words
Imipramine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through different pharmacodynamic pathways.
What to do
Use the lowest effective doses with gradual titration; monitor for sedation, falls and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Imipramine with Pregabalin?
MediHelp rates the interaction as moderate. Imipramine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, dizziness and impaired psychomotor performance, which can be additive. Respiratory depression is a concern in vulnerable patients or with other CNS depressants.
How serious is the interaction between Imipramine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses with gradual titration; monitor for sedation, falls and respiratory depression.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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