Drug interactions
Imipramine + Propylhexedrine
Severity: Moderate
Imipramine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled sympathomimetic decongestant, and tricyclics may potentiate adrenergic effects when it is absorbed systemically. This could cause hypertension, tachycardia or arrhythmia, especially with overuse.
What this interaction means in plain words
Imipramine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Tricyclic blockade of norepinephrine reuptake enhances sympathomimetic effects.
What to do
Advise strict adherence to recommended inhaler use and monitor blood pressure and pulse. Choose a non-sympathomimetic decongestant if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Imipramine with Propylhexedrine?
MediHelp rates the interaction as moderate. Imipramine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is an inhaled sympathomimetic decongestant, and tricyclics may potentiate adrenergic effects when it is absorbed systemically. This could cause hypertension, tachycardia or arrhythmia, especially with overuse.
How serious is the interaction between Imipramine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict adherence to recommended inhaler use and monitor blood pressure and pulse. Choose a non-sympathomimetic decongestant if possible.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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