Drug interactions
Imipramine + Risperidone
Severity: Moderate
Imipramine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and cause sedation and orthostatic hypotension. Imipramine may also raise risperidone exposure through CYP2D6 competition.
What this interaction means in plain words
Imipramine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT and CNS effects, with CYP2D6 competition raising concentrations.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and monitor sedation, blood pressure and extrapyramidal effects. Adjust risperidone or imipramine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Imipramine with Risperidone?
MediHelp rates the interaction as moderate. Imipramine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and cause sedation and orthostatic hypotension. Imipramine may also raise risperidone exposure through CYP2D6 competition.
How serious is the interaction between Imipramine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and monitor sedation, blood pressure and extrapyramidal effects. Adjust risperidone or imipramine dose as needed.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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