Drug interactions
Imipramine + Rucaparib
Severity: Moderate
Imipramine and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C19 and several other CYP enzymes, which may raise imipramine concentrations. Higher exposure can increase anticholinergic, sedative and cardiac effects.
What this interaction means in plain words
Imipramine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP2C19 (and possibly CYP2D6) metabolism of imipramine by rucaparib.
What to do
Monitor for signs of tricyclic toxicity and adjust the imipramine dose according to response. Consider an ECG or plasma level monitoring if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Imipramine with Rucaparib?
MediHelp rates the interaction as moderate. Imipramine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP2C19 and several other CYP enzymes, which may raise imipramine concentrations. Higher exposure can increase anticholinergic, sedative and cardiac effects.
How serious is the interaction between Imipramine and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of tricyclic toxicity and adjust the imipramine dose according to response. Consider an ECG or plasma level monitoring if symptoms occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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