Drug interactions
Imipramine + Sevoflurane
Severity: Moderate
Imipramine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics may increase the risk of arrhythmias and hypotension under volatile anesthesia, and sevoflurane can itself prolong the QT interval. Sedative effects are additive.
What this interaction means in plain words
Imipramine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction and CNS and cardiovascular depression.
What to do
Perform continuous ECG and blood pressure monitoring during anesthesia and review the preoperative ECG. Avoid sympathomimetic pressors where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Imipramine with Sevoflurane?
MediHelp rates the interaction as moderate. Imipramine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclics may increase the risk of arrhythmias and hypotension under volatile anesthesia, and sevoflurane can itself prolong the QT interval. Sedative effects are additive.
How serious is the interaction between Imipramine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform continuous ECG and blood pressure monitoring during anesthesia and review the preoperative ECG. Avoid sympathomimetic pressors where possible.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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