Drug interactions
Imipramine + Stiripentol
Severity: Moderate
Imipramine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes including CYP2C19 and may raise imipramine and desipramine levels, increasing anticholinergic, cardiac and seizure risk. Additive sedation is also possible.
What this interaction means in plain words
Imipramine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19 (and CYP1A2, CYP3A4), reducing imipramine clearance, with additive CNS depression.
What to do
Start with a lower imipramine dose and titrate by response, tolerability and plasma levels. Monitor for sedation and ECG changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Imipramine with Stiripentol?
MediHelp rates the interaction as moderate. Imipramine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes including CYP2C19 and may raise imipramine and desipramine levels, increasing anticholinergic, cardiac and seizure risk. Additive sedation is also possible.
How serious is the interaction between Imipramine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower imipramine dose and titrate by response, tolerability and plasma levels. Monitor for sedation and ECG changes.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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