Drug interactions
Imipramine + Tedizolid
Severity: Moderate
Imipramine and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine inhibits serotonin and norepinephrine reuptake, and tedizolid weakly inhibits MAO. Serotonin syndrome is theoretically possible, though clinical evidence is limited.
What this interaction means in plain words
Imipramine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Theoretical additive serotonergic effect from weak MAO inhibition plus monoamine reuptake inhibition.
What to do
Monitor for serotonin toxicity and blood pressure changes during co-administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Tedizolid?
MediHelp rates the interaction as moderate. Imipramine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine inhibits serotonin and norepinephrine reuptake, and tedizolid weakly inhibits MAO. Serotonin syndrome is theoretically possible, though clinical evidence is limited.
How serious is the interaction between Imipramine and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and blood pressure changes during co-administration.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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