Drug interactions
Imipramine + Tiotropium-olodaterol
Severity: Moderate
Imipramine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine has strong anticholinergic effects that add to tiotropium and may cause urinary retention, constipation, dry mouth and raised intraocular pressure. Tricyclics also prolong the QT interval and can potentiate the cardiovascular effects of beta2 agonists, raising arrhythmia risk.
What this interaction means in plain words
Imipramine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive QT and adrenergic cardiovascular effects.
What to do
Monitor ECG in patients with cardiac risk factors and watch for anticholinergic adverse effects. Correct potassium abnormalities and consider dose reduction if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Imipramine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine has strong anticholinergic effects that add to tiotropium and may cause urinary retention, constipation, dry mouth and raised intraocular pressure. Tricyclics also prolong the QT interval and can potentiate the cardiovascular effects of beta2 agonists, raising arrhythmia risk.
How serious is the interaction between Imipramine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and watch for anticholinergic adverse effects. Correct potassium abnormalities and consider dose reduction if effects occur.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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