Drug interactions
Imipramine + Triclabendazole
Severity: Minor
Imipramine and Triclabendazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole may increase imipramine exposure through CYP2C19 inhibition, potentially increasing tricyclic adverse effects. The effect is probably modest.
What this interaction means in plain words
Imipramine and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Triclabendazole and its metabolites inhibit CYP2C19, decreasing imipramine demethylation.
What to do
Monitor for sedation, anticholinergic effects and palpitations during the short treatment course, and reduce imipramine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Imipramine with Triclabendazole?
MediHelp rates the interaction as minor. Imipramine and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclabendazole may increase imipramine exposure through CYP2C19 inhibition, potentially increasing tricyclic adverse effects. The effect is probably modest.
How serious is the interaction between Imipramine and Triclabendazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects and palpitations during the short treatment course, and reduce imipramine dose if needed.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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