Drug interactions
Indacaterol + Isocarboxazid
Severity: Major
Indacaterol and Isocarboxazid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to palpitations, tachycardia, blood pressure changes and arrhythmia. QT effects may also be additive.
What this interaction means in plain words
Indacaterol and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibition increases sympathomimetic amine activity, augmenting the adrenergic cardiovascular effects of the beta-2 agonist.
What to do
Avoid combining where possible, or monitor heart rate, blood pressure and ECG closely. Consider an alternative bronchodilator regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Indacaterol with Isocarboxazid?
MediHelp rates the interaction as major. Indacaterol and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to palpitations, tachycardia, blood pressure changes and arrhythmia. QT effects may also be additive.
How serious is the interaction between Indacaterol and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor heart rate, blood pressure and ECG closely. Consider an alternative bronchodilator regimen.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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