Drug interactions
Indacaterol + Lefamulin
Severity: Moderate
Indacaterol and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, and indacaterol may add cardiac stimulation and hypokalemia. This increases arrhythmia risk, mainly in patients with other QT risk factors.
What this interaction means in plain words
Indacaterol and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation.
What to do
Check ECG in patients with cardiac risk factors and correct electrolyte disturbances. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Indacaterol with Lefamulin?
MediHelp rates the interaction as moderate. Indacaterol and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin can prolong the QT interval, and indacaterol may add cardiac stimulation and hypokalemia. This increases arrhythmia risk, mainly in patients with other QT risk factors.
How serious is the interaction between Indacaterol and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG in patients with cardiac risk factors and correct electrolyte disturbances. Monitor for palpitations or syncope.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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